Eighteen people were killed and three injured in an explosion of two mines planted by terrorists groups in the east of the Syrian province of Hama, according to the Syrian state agency SANA.
The explosion reportedly occurred in the Wadi al-Azib area near the city of al-Salamiyah.
The Britain-based Syrian Observatory for Human Rights war monitor said the victims were likely truffle farmers.
Across Syria, over 10 million people live in areas contaminated by explosive hazards, according to the United Nations.
Truffle digging has seen many people, including women and children, lose their lives in the region in recent years.
Recent data shows that, almost nine years of civil war in Syria has left more than 380,000 people dead including over 115,000 civilians.